BackgroundCoronary resistance microvessels (CRMs) from type 2 diabetic (T2DM) mice and pigs are less stiff compared to normal. a finding that is dictated by less stiff coronary vascular smooth muscle cells (VSMCs). Cofilin is an endogenous actin regulatory protein that depolymerizes filamentous (F)-actin. and portions of F-actin bound to cofilin are less stiff compared to their unboun... https://www.knowall.blog/