Objectives: To compare the effects of the Shouzu Ning Decoction (SND) and Halometasone plus Celecoxib (Hal/Cxb) as therapy in patients with grade 2 hand-foot skin reaction (HFSR). Materials and Methods: Fifty patients with grade 2 HFSR participated in a randomized. single-center. open-label study. https://www.bekindtopets.com/limited-stock-Bovi-Shield-Gold-FP-5-L5-HB-best-super/