The increased spontaneous fragility in the centromere regions of the chromosomes predisposes to abnormal cellular division due to abnormal interaction with the mitotic spindle. which leads to number chromosomal aberrations. The abnormal structure of the microtubule-associated proteins (MAPs) could also be among the internal factors. predisposing to these pathologies. https://www.hindigyanvishv.com/hot-find-Facia-Installation-Kit-Suits-Holden-Commodore-VE-Series-2-FP9550BK-Black-top-mega/